Song lab (Laboratory of Molecular Developmental Genetics) has been focusing on understanding uterine environments for successful embryo implantation, called uterine receptivity, using various knockout mouse models, and various patho-physiologic conditions of obstetrics & gynecology, such as Asherman’s syndrome and preterm labor.
1. Uterine receptivity for embryo implantation using conditional knockout (cKO) mice with multiple Cre system
We have been extensively investigating molecular mechanisms of uterine receptivity for embryo implantation using various conventional KO and cKO mouse models deficient of key factors involved in hormone responses, microRNA biogenesis, epigenetics, and autophagy. We have been applying various Cre systems to produce cKO mice where a gene of interest is deleted in female reproductive tracts in a cell-type specific manner.
- An autophagic deficit in the uterine vessel microenvironment provokes hyperpermeability through deregulated VEGFA, NOS1, and CTNNB1. Autophagy (2020) (In press)
- Estrogen induces EGR1 to modulate its actions on uterine epithelial cells by controlling PR signaling for successful embryo implantation. FASEB J (2018) 32(3):1184-1195
- Estrogen-induced transcription factor EGR1 regulates c-Kit transcription in mouse uterus to maintain uterine receptivity for embryo implantation. Mol Cell Endocrinol (2018) 470:75-83
- Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice. Scientific Reports (2016) 6:20242
경기도 성남시 분당구 판교로 335 차바이오컴플렉스 (차병원그룹 판교종합연구원) 624호
335, Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea
TEL : 031-881-7236
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